| Identification | Back Directory | [Name]
Genz-123346 | [CAS]
491833-30-8 | [Synonyms]
CS-1436
Genz-123346
Eliglustat Impurity 7
Genz-123346 (free base)
GENZ-123346; GENZ123346; GENZ 123346
N-((1R,2R)-1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)no
N-[(1R,2R)-2-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-2-HYDROXY-1-(1-PYRROLIDINYLMETHYL)ETHYL]-NONANAMIDE
Nonanamide, N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-
N-[(1R,2R)-1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl]nonanamide Genz-123346 | [Molecular Formula]
C24H38N2O4 | [MDL Number]
MFCD22419854 | [MOL File]
491833-30-8.mol | [Molecular Weight]
418.57 |
| Chemical Properties | Back Directory | [Boiling point ]
623.9±55.0 °C(Predicted) | [density ]
1.111±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:84.0(Max Conc. mg/mL);200.68(Max Conc. mM)
Ethanol:84.0(Max Conc. mg/mL);200.68(Max Conc. mM) | [form ]
A crystalline solid | [pka]
13.45±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GENZ-123346 potently controls hyperglycemia in obese rodent models of insulin resistance. | [Biological Activity]
Cell permeable: yes', 'Primary Target
glucosylceramide synthase', 'Reversible: yes', 'Target IC50: 14 nM for ganglioside GM1 suppression |
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