| Identification | Back Directory | [Name]
(3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one | [CAS]
486443-73-6 | [Synonyms]
LC3-mHTT-IN-AN1
LC3-mHTT-IN-AN1 (Compound AN1)
(3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one
2H-Indol-2-one, 5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylene]-1,3-dihydro- | [Molecular Formula]
C15H9Br2NO3 | [MDL Number]
MFCD03235520 | [MOL File]
486443-73-6.mol | [Molecular Weight]
411.04 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO: 125 mg/mL (304.11 mM) | [form ]
A solid | [color ]
Light yellow to yellow | [Water Solubility ]
Water: < 0.1 mg/mL (insoluble) |
| Hazard Information | Back Directory | [Biological Activity]
AN1 is a brain blood barrier penetrant agent th at tether LC3 and mHTT and targets mHTT for autophagosome degradation. AN1 significantly lower mHTT in cortices of HD micein cells from patients with Huntington′s diseaseand neurons derived from induced pluripotent stem cells. AN1 does not lower wtHTT in fibroblasts from healthy human donors. It appears th at AN1 interact with the polyQ stretch. |
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Twochem Co.Ltd.
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021-58111628 15800915896 |
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cn.twochem.com |
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DC Chemicals
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http://m.is0513.com/ShowSupplierProductsList927327/0.htm |
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