| Identification | Back Directory | [Name]
Thiosildenafil | [CAS]
479073-79-5 | [Synonyms]
xidi
Sildenafil N
Thiosildenafil
Sildenafil Impurity N
Demethyltadalafil Solution, 100ppm
5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidine-7-thione
5-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-thione
7H-Pyrazolo[4,3-d]pyrimidine-7-thione, 5-[2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-
Sildenafil Impurity 23/Thiosildenafil/5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-thione | [Molecular Formula]
C22H30N6O3S2 | [MDL Number]
MFCD11977921 | [MOL File]
479073-79-5.mol | [Molecular Weight]
490.64 |
| Chemical Properties | Back Directory | [Melting point ]
172-174?C | [Boiling point ]
676.1±65.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
5.97±0.42(Predicted) | [color ]
Pale Yellow to Light Yellow |
| Hazard Information | Back Directory | [Description]
Thiosildenafil is a derivative of the phosphodiesterase 5 (PDE5) inhibitor sildenafil (Item No. 10008671).1 | [Chemical Properties]
Pale Yellow Solid | [Uses]
An analog of labelled Sildenafil; a novel pyrazolopyrimidinethiones as PDE5 inhibitor. | [Uses]
An analog of Sildenafil; a novel pyrazolopyrimidinethiones as PDE5 inhibitor. | [Uses]
Sildenafil, marketed under the trade name Viagra?, is a potent cGMP-specific phosphodiesterase inhibitor that is highly selective for PDE5. While most notable for its use in the treatment of erectile dysfunction, sildenafil’s vasorelaxant properties have also been used to control vascular tone in pulmonary arterial hypertension and high-altitude pulmonary edema associated with altitude sickness. Thiosildenafil is a derivative of sildenafil that has been found as an adulterant in dietary supplements advertising sexual enhancement for men. The biological characteristics of thiosildenadil have not been reported.[Cayman Chemical] |
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