| Identification | Back Directory | [Name]
Obtusifolin | [CAS]
477-85-0 | [Synonyms]
Obtusifolin
Obtusifolin (anthraquinone)
Obtusifolin ISO 9001：2015 REACH
2,8-Dihydroxy-1-Methoxy-3-Methylanthraquinone
Anthraquinone, 2,8-dihydroxy-1-methoxy-3-methyl-
2,8-Dihydroxy-1-methoxy-3-methyl-9,10-anthracenedione
2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione
9,10-Anthracenedione, 2,8-dihydroxy-1-methoxy-3-methyl- | [EINECS(EC#)]
805-819-4 | [Molecular Formula]
C16H12O5 | [MDL Number]
MFCD18452296 | [MOL File]
477-85-0.mol | [Molecular Weight]
284.26 |
| Chemical Properties | Back Directory | [Melting point ]
242-243℃ | [Boiling point ]
528.0±50.0 °C(Predicted) | [density ]
1.448±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
2-8°C | [solubility ]
DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml | [form ]
A solid | [pka]
6.60±0.20(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway[1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein[2]. | [Definition]
ChEBI: Obtusifolin is a dihydroxyanthraquinone. | [General Description]
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG | [IC 50]
NF-κB | [References]
[1] Choi BS, et al. Obtusifolin isolated from the seeds of Cassia obtusifolia regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via affecting NF-κB pathway. Phytother Res. 2019 Apr;33(4):919-928. DOI:10.1002/ptr.6284
[2] Hsu YL, et al. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein. J Agric Food Chem. 2014 Dec 10;62(49):11933-40. DOI:10.1021/jf5042905 |
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