| Identification | Back Directory | [Name]
1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]- | [CAS]
467459-31-0 | [Synonyms]
LU AE58054
LU AE58084
idalopirdine
LU AE58054(Idalopirdine)
Idalopirdine(Lu-AE-58054)
IDALOPIRDINE;LU AE 58054;LUAE58054
LU AE58054 HYDROCHLORIDE; LU AE 58054 HYDROCHLORIDE
N-[2-(6-Fluoro-1H-indol-3-yl)ethyl]-3-(2,2,3,3-tetrafluoropropoxy)benzylamine
6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]-1H-Indole-3-ethanamine
1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]-
2-(6-fluoro-1H-indol-3-yl)-N-[[3-(2,2,3,3-tetrafluoropropoxy)phen yl]methyl]ethanamine | [Molecular Formula]
C20H19F5N2O | [MDL Number]
MFCD18633269 | [MOL File]
467459-31-0.mol | [Molecular Weight]
398.37 |
| Chemical Properties | Back Directory | [Boiling point ]
500.9±50.0 °C(Predicted) | [density ]
1.309±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
25℃: DMSO | [form ]
Powder | [pka]
16.63±0.30(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
The selective and high affinity 5-?HT6 receptor antagonist Lu AE58054 as promising treatment for cognitive disorders, in particular for Alzheimer’s disease (AD). | [Biological Activity]
Idalopirdine (Lu AE58054) is an orally availableand potent antagonist of the serotonin 6 (5-HT6) receptor. Idalopirdine has been reported to be highly selective over other G-protein coupled receptors. It has K(d) of 0.2nM for the 5-HT6 receptor with 16-fold selectivity over the 5-HT2A receptor (K(i) 3.2nM) and >100-fold selectivity to all other evaluated targets. |
|
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Tel: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
|