| Identification | Back Directory | [Name]
neritaloside | [CAS]
465-13-4 | [Synonyms]
neritaloside
Card-20(22)-enolide, 16-(acetyloxy)-3-[(6-deoxy-3-O-methyl-β-D-galactopyranosyl)oxy]-14-hydroxy-, (3β,5β,16β)- | [Molecular Formula]
C32H48O10 | [MDL Number]
MFCD01740131 | [MOL File]
465-13-4.mol | [Molecular Weight]
592.73 |
| Hazard Information | Back Directory | [Uses]
Neritaloside could be isolated from nerium oleander. Neritaloside has central nervous system (CNS) depressant effect[1][2. | [in vivo]
Neritaloside (25 mg/kg; i.p.; for 6 hours; mice of NMRI strain) exhibits central nervous system depressant activity in mice at a dose of 25 mg/kg[2. | Animal Model: | Mice of NMRI strain (18-22 g) [2 | | Dosage: | 25 mg/kg | | Administration: | Intraperitoneal injection; for 6 hours | | Result: | Showed sedation in mice at 25 mg/kg dose. |
| [References]
[1] Rashan LJ, et, al. Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum. J Ethnopharmacol. 2011 Apr 12;134(3):781-8. DOI:10.1016/j.jep.2011.01.038
[2] Begum S, et, al. Bio-active cardenolides from the leaves of Nerium oleander. Phytochemistry. 1999 Feb;50(3):435-8. DOI:10.1016/s0031-9422(98)00523-8 |
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