| Identification | Back Directory | [Name]
FLUOROCHOLINE | [CAS]
459424-38-5 | [Synonyms]
FCH
FCH CHLORIDE
FLUOROCHOLINE
FLUOROCHLOLINE
FLUOROCHOLINE CHLORIDE
FLUOROMETHYLCHOLINE CHLORIDE
N,N-DIMETHYL-N-(FLUOROMETHYL) ETHANOLAMMONIUM CHLORIDE
DIMETHYL(FLUOROMETHYL)(2-HYDROXYETHYL)AMMONIUM CHLORIDE
ETHANAMINIUM, N-(FLUOROMETHYL)-2-HYDROXY-N,N-DIMETHYL-, CHLORIDE
Dimethyl(fluoromethyl)(2-hydroxyethyl)ammonium chloride, N,N-Dimethyl-N-(fluoromethyl)-2-hydroxyethanaminium chloride | [Molecular Formula]
C5H13ClFNO | [MDL Number]
MFCD07995053 | [MOL File]
459424-38-5.mol | [Molecular Weight]
157.61 |
| Chemical Properties | Back Directory | [Appearance]
Colourless crystals, very sensitive to moisture (hygroscopic) | [Melting point ]
184-185 | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [CAS DataBase Reference]
459424-38-5 |
| Hazard Information | Back Directory | [Chemical Properties]
Colourless crystals, very sensitive to moisture (hygroscopic) | [Uses]
Fluorocholine (chloride) is a biochemical reagent that can be used as a biological material or organic compound for life science related research[1]. | [Biological Activity]
FMC is a monofluorinated choline th at acts as a nonlethalmechanism-based irreversible inhibtor (pseudosubstrate-based suicide inhibitor) against gut anaerobic bacterial glycyl radical enzyme (GRE) cutC choline trimethylamine (TMA) lyase-catalyzed TMA production from choline (IC50 = 0.9 nM/P. mirabilis & 1.4 nM/D. alaskensis rec. CutC/D) without affecting the bacterial growth (P. mirabilisE. fergusoniiand P. penneri). A single FMC oral dose (100 mg/kg) to mice on choline-supplemented diet significantly reduces plasma trimethylamine N-oxide (TMAO) level (up to 3 days) as well as diet-induced platelet responsiveness and thrombus formation without toxicity or increased bleeding risk. | [References]
[1] Bergmeyer H U, et al. Biochemical reagents[M]//Methods of Enzymatic Analysis. Academic Press, 1965: 967-1037. |
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