| Identification | More | [Name]
Diglycolic anhydride | [CAS]
4480-83-5 | [Synonyms]
1,4-DIOXANE-2,6-DIONE
1,4-DIOXINE-2,6-DIONE
DIGLYCOLIC ANHYDRIDE
Acetic acid, 2,2'-oxybis-, cyclic anhydride
Acetic acid, oxydi-, cyclic anhydride
Diglycolic acid anhydride
Oxydiacetic anhydride
p-Dioxane-2,6-dione
DIGLYCOLIC ANHYDRIDE, TECH., 90%
Diglycolicanhydride,95% | [EINECS(EC#)]
224-761-5 | [Molecular Formula]
C4H4O4 | [MDL Number]
MFCD00006677 | [Molecular Weight]
116.07 | [MOL File]
4480-83-5.mol |
| Chemical Properties | Back Directory | [Appearance]
white to off-white | [Melting point ]
92-93 °C (lit.) | [Boiling point ]
240-241 °C (lit.) | [density ]
1.4230 | [refractive index ]
1.5800 (estimate) | [Fp ]
240-241°C | [storage temp. ]
Store below +30°C. | [solubility ]
Soluble in chloroform. | [form ]
Crystalline Powder, Crystals or Needles | [color ]
White to pale cream | [Sensitive ]
Moisture Sensitive | [BRN ]
112527 | [Stability:]
Hygroscopic, Moisture Sensitive | [InChIKey]
PIYNUZCGMLCXKJ-UHFFFAOYSA-N | [CAS DataBase Reference]
4480-83-5(CAS DataBase Reference) | [NIST Chemistry Reference]
1,4-Dioxane-2,6-dione(4480-83-5) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
2923 | [WGK Germany ]
3
| [F ]
10-21 | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29189090 |
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white | [Uses]
Diglycolic anhydride is used in the preparation of N,N-diethyldiglycollamsaeure by reacting with diethylamine. It is an useful bio chemical for proteomics research. | [Synthesis]
50.01 g of diglycolic acid was dissolved in 140 mL of acetic anhydride, Heated to 145 ℃, Add 5 drops of phosphoric acid as initiator, And the mixture was refluxed for 2 hours. After the reaction was stopped, Most acetic anhydride was removed by rotary evaporation at 80 ℃. Approximately 100 mL of liquid was obtained,300 mL of toluene was added. Stirring, and allowed to stand for 10 hours. Vacuum filtration to give 38.89g colourless to white Diglycolic anhydride crystals. The yield was 90%.
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