| Identification | Back Directory | [Name]
SB-756050 | [CAS]
447410-57-3 | [Synonyms]
SB-756050
SB-756050, >98%
SB756050;SB 756050;SB-756050
1,4-bis((3,4-dimethoxyphenyl)sulfonyl)-1,4-diazepane
1H-1,4-Diazepine, 1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]hexahydro- | [Molecular Formula]
C21H28N2O8S2 | [MDL Number]
MFCD02585318 | [MOL File]
447410-57-3.mol | [Molecular Weight]
500.59 |
| Chemical Properties | Back Directory | [Boiling point ]
653.1±65.0 °C(Predicted) | [density ]
1.328±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.25 mg/ml; DMSO: 10 mg/ml | [form ]
A crystalline solid | [pka]
-6.97±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
SB-756050 is an agonist of the bile acid G protein-coupled receptor TGR5 (EC50 = 1.3 μM for the human receptor). It is selective for TGR5 over the farnesoid X receptor (FXR) and a panel of other receptors, channels, and transporters. SB-756050 (10-100 mg/kg) decreases fasting glucose levels and increases glucose disposal rate and insulin secretion in diabetic Goto Kakizaki rats. |
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| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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