| Identification | Back Directory | [Name]
(8R)-8-ETHYL-1,4,7,8-TETRAHYDRO-4-5H-IMIDAZO[2,1-I]PURIN-5-ONE | [CAS]
444717-56-0 | [Synonyms]
PSB 11 HYDROCHLORIDE
(8R)-8-ETHYL-1,4,7,8-TETRAHYDRO-4-5H-IMIDAZO[2,1-I]PURIN-5-ONE
(8R)-8-ETHYL-1,4,7,8-TETRAHYDRO-4-5H-IMIDAZO[2,1-I]PURIN-5-ONE HYDROCHLORIDE
5H-Imidazo[2,1-i]purin-5-one, 8-ethyl-3,4,7,8-tetrahydro-4-methyl-2-phenyl-, (8R)- | [Molecular Formula]
C16H17N5O | [MDL Number]
MFCD06798317 | [MOL File]
444717-56-0.mol | [Molecular Weight]
295.34 |
| Hazard Information | Back Directory | [Uses]
PSB 11 Hydrochloride is a potent and selective antagonist of Adenosine receptor A3-R. | [Biological Activity]
Potent and selective antagonist for the human adenosine A 3 receptor, with low affinity for the rat A 3 receptor (K i values are 2.3 and > 10000 nM respectively). Displays > 1000-fold selectivity over human A 1 and A 2A receptors (K i values are 4.1 and 3.3 μ M respectively) and > 180-fold selectivity over rat A 1 , rat A 2A and mouse A 2B receptors. Acts as an inverse agonist in the [ 35 S]GTP γ S binding assay in hA 3 -CHO cells (IC 50 = 36 nM). |
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