| Identification | Back Directory | [Name]
CPI-444 | [CAS]
443103-97-7 | [Synonyms]
A2AR antagonist 1
A2A receptor antagonist 1
1-(2-fluorobenzyl)-4-(furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine
1H-Pyrazolo[3,4-d]pyrimidin-6-amine, 1-[(2-fluorophenyl)methyl]-4-(2-furanyl)-
CPI444,CPI 444,Adenosine Receptor,disease,Parkinson,Inhibitor,CPI-444,hypolocomotion,inhibit,model,P1 receptor | [Molecular Formula]
C16H12FN5O | [MDL Number]
MFCD31544344 | [MOL File]
443103-97-7.mol | [Molecular Weight]
309.3 |
| Chemical Properties | Back Directory | [Boiling point ]
570.6±60.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 62 mg/mL (200.45 mM) | [form ]
Solid | [pka]
3.17±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
A2A receptor antagonist 1 (CPI-444 analog) is an antagonist of both adenosine A2A receptor and A1 receptor with Ki values of 4 and 264 nM, respectively[1]. | [storage]
Store at -20°C | [References]
[1] Gillespie RJ, et al. Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines. Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9. DOI:10.1016/j.bmcl.2008.03.072 |
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BOC Sciences
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