| Identification | Back Directory | [Name]
1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE | [CAS]
4430-35-7 | [Synonyms]
6-HITC
6-MITC
6-MITC; 6 MITC; 6MITC
6-METHYLSULFINYLHEXYL ISOTHIOCYANATE
1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE
Hexane, 1-isothiocyanato-6-(methylsulfinyl)- | [Molecular Formula]
C8H15NOS2 | [MDL Number]
MFCD03093720 | [MOL File]
4430-35-7.mol | [Molecular Weight]
205.34 |
| Chemical Properties | Back Directory | [Boiling point ]
385.9±25.0 °C(Predicted) | [density ]
1.12±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator, under inert atmosphere | [solubility ]
Chloroform (Sparingly), Methanol (Slightly) | [form ]
Oil | [color ]
Colourless to Pale Yellow | [LogP]
0.959 (est) |
| Hazard Information | Back Directory | [Description]
6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is an isothiocyanate that has been found in wasabi (W. japonica) and has diverse biological activities. It inhibits nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at a concentration of 5 μM. It inhibits aggregation of isolated human platelets induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607; IC50 = 21.9 μM). 6-MSITC reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 μM). In vivo, 6-MSITC (5 mg/kg twice weekly) reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of Parkinson''s disease induced by 6-OHDA . 6-MSITC also reduces the number of lung metastases in a B16/F10 murine melanoma model. | [Uses]
6-(Methylsulfinyl)hexyl isothiocyanate derived from Wasabia japonica was discovered as an inhibitor of glycogen synthase kinase-3β. | [Definition]
ChEBI: 1-isothiocyanato-6-(methylsulfinyl)hexane is a sulfoxide. |
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