| Identification | Back Directory | [Name]
KOdiA-PC | [CAS]
439904-33-3 | [Synonyms]
KOdiA-PC
KOdiA-PC Exclusive
PEZXEQJZQAVYCZ-NLMPBQEBSA-N | [Molecular Formula]
C32H58NO11P | [MDL Number]
MFCD12912356 | [MOL File]
439904-33-3.mol | [Molecular Weight]
663.79 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -80°C, protect from light | [solubility ]
DMF: .5 mg/ml; DMSO: .5 mg/ml; Ethanol: 30 mg/ml; PBS (pH7.2): 5 mg/ml | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic.1 Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position.2 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl) phosphatidylcholine, or KOdiA-PC, is one of the most potent CD36 ligands among the oxLDL species.3 KOdiA-PC confers CD36 scavenger receptor binding affinity to LDL at a frequency of only 2 to 3 KOdiA-PC molecules/LDL particle, and may be one of the more important structural determinants of oxLDL. | [Definition]
ChEBI: PKODiA-PC is a 1,2-diacyl-sn-glycero-3-phosphocholine. | [storage]
Store at -80°C, protect from light | [References]
1. Podrez, E.A., Febbraio, M., Sheibani, N., et al. Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species J. Clin. Invest. 105(8),1095-1108(2000).
2. Podrez, E.A., Poliakov, E., Shen, Z., et al. A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions J. Biol. Chem. 277(41),38517-38523(2002).
3. Podrez, E.A., Poliakov, E., Shen, Z., et al. Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36 J. Biol. Chem. 277(41),38503-38516(2002). |
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