| Identification | Back Directory | [Name]
Glucagon Receptor Antagonist I | [CAS]
438618-32-7 | [Synonyms]
Glucagon Receptor Antagonist I
N-[3-cyano-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-2-ethylbutanamide | [Molecular Formula]
C20H30N2OS | [MDL Number]
MFCD01920208 | [MOL File]
438618-32-7.mol | [Molecular Weight]
346.53 |
| Hazard Information | Back Directory | [Description]
Glucagon receptor antagonist I is a competitive antagonist of the glucagon receptor (GCGR; IC50 = 181 nM). It blocks glucagon-induced glycogenolysis in primary human hepatocytes and isolated liver. Glucagon receptor antagonist I, at 50 mg/kg, reduces the increase in glucose levels observed after intraperitoneal administration of glucagon in humanized mice. Glucagon receptor antagonist inactive control does not prevent glucagon-mediated actions. | [storage]
Store at -20°C |
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