| Identification | Back Directory | [Name]
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid | [CAS]
437655-95-3 | [Synonyms]
Fmoc-PEG4- CH2COOH
Fmoc-NH-PEG4-CH2CO2H
Fmoc-NH-PEG5-CH2CO2H
FMoc-NH-PEG4-CH2COOH
Fmoc-PEG4-acetic acid
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
1-Hydroxy-1-oxo-5,8,11,14-tetraoxa-2-azahexadecan-16-oic acid
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid
14-[(9-Fluorenylmethoxycarbonyl)amino]-3,6,9,12-tetraoxatetradecanoic acid
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid 1-(9H-fluoren-9-ylmethyl) ester
14-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,6,9,12-tetraoxatetradecanoic acid
[2-(2-{2-[2-((9H-fluoren-9-yl-methoxycarbonyl)amino)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid | [Molecular Formula]
C25H31NO8 | [MDL Number]
MFCD26142981 | [MOL File]
437655-95-3.mol | [Molecular Weight]
473.52 |
| Chemical Properties | Back Directory | [Melting point ]
51℃ | [Boiling point ]
681.3±55.0 °C(Predicted) | [density ]
1.235±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [form ]
Oil | [pka]
3.39±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Fmoc-NH-PEG4-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Biological Activity]
Fmoc-NH-PEG4-CH2COOH is a degradable ADC linker for antibody drug conjugate (ADC) synthesis. It is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis. | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | [target]
| Cleavable | Alkyl/ether | PEGs | |
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