| Identification | Back Directory | [Name]
JKC-363 | [CAS]
436083-30-6 | [Synonyms]
JKC-363
(DeaMino-Cys11,D-2-Nal14,Cys18)-b-MSH (11-22) aMide
(Deamino-Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide
(DEAMINO-CYS11,D-2-NAL14,CYS18)-BETA-MSH (11-22) AMIDE
MPR-GLU-HIS-D-NAL(2)-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2
(Deamino-Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide, JKC-363
(Deamino-Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide, JKC-363
(DEAMINO-CYS11,D-ALA(2-NAPHTHYL)14,CYS18)-BETA-MSH (11-22) AMIDE
3-MERCAPTOPROPIONYL-GLU-HIS-D-2-NAL-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2
(Deamino-Cys11,D-2-Nal 14,Cys18)-b-MSH (11-22) amide trifluoroacetate salt
Mpr-Glu-His-D-Nal(2)-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge Mpr1-Cys8)
[DEAMINO-CYS11, B-(2-NAPHTHYL)-D-ALA14, CYS18]-BETA-MELANOCYTE STIMULATING HORMONE AMIDE FRAGMENT 11-22
[Deamino-Cys11, β-(2-Naphthyl)-D-Ala14, Cys18]-β-Melanocyte Stimulating Hormone Amide Fragment 11-22
L-α-Asparagine, N-(3-mercapto-1-oxopropyl)-L-α-glutamyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cysteinyl-L-prolyl-L-prolyl-L-lysyl-, cyclic (1→7)-disulfide | [Molecular Formula]
C69H91N19O16S2 | [MDL Number]
MFCD06636638 | [MOL File]
436083-30-6.mol | [Molecular Weight]
1506.71 |
| Chemical Properties | Back Directory | [density ]
1.56±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C | [form ]
Powder | [pka]
4.07±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble to 1 mg/ml in water |
| Hazard Information | Back Directory | [Uses]
JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect[1][2]. | [IC 50]
MC4R | [References]
[1] Kim MS, et al. Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: evidence for the differential roles of melanocortin 3 and 4 receptors. J Neuroendocrinol. 2002;14(4):276-282. DOI:10.1046/j.1365-2826.2002.00769.x
[2] Bellasio S, et al. Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur J Pharmacol. 2003;482(1-3):127-132. DOI:10.1016/j.ejphar.2003.09.017 |
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