| Identification | Back Directory | [Name]
(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide | [CAS]
432531-71-0 | [Synonyms]
Necrosulfonami
Necrosulfonamide(b)
Necrosulfonamide HCl
(E/Z)-Necrosulfonamide
MLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem
N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide
N-[4-[[(3-Methoxypyrazinyl)aMino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenaMide
(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide
(E)-N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide
2-Propenamide, N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)- | [Molecular Formula]
C18H15N5O6S2 | [MOL File]
432531-71-0.mol | [Molecular Weight]
461.47 |
| Chemical Properties | Back Directory | [storage temp. ]
+2C to +8C | [solubility ]
DMSO:100.0(Max Conc. mg/mL);216.7(Max Conc. mM) | [form ]
Dark yellow solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway. | [Uses]
Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis)
pathway. | [Definition]
ChEBI: Necrosulfonamide is a sulfonamide that is a 3-methoxypyrazin-2-yl derivative of (E)-N-(4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide. Necrosulfonamide specifically blocks necrosis downstream of the activation of RIP3 (the receptor-interacting serine-threonine kinase 3), a key signalling molecule in the programmed necrosis (necroptosis) pathway. It is a sulfonamide, a member of pyrazines and a member of thiophenes. | [Biological Activity]
Cell permeable: yes''Primary Target
human MLKL''Reversible: no | [storage]
Store at -20°C |
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| Company Name: |
Struchem Co., Ltd.
|
| Tel: |
0512-0512-63009836 15365350169 |
| Website: |
http://www.struchem.com |
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