| Identification | Back Directory | [Name]
NS 5806 | [CAS]
426834-69-7 | [Synonyms]
NS 5806
N-[3,5-bis(trifluoromethyl)phenyl]-N′-[2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl]-urea
N-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]--N'-[2,4-DIBROMO-6-(2H-TETRAZOL-5-YL)PHENYL]UREA
Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]- | [Molecular Formula]
C16H8Br2F6N6O | [MDL Number]
MFCD18432708 | [MOL File]
426834-69-7.mol | [Molecular Weight]
574.07 |
| Chemical Properties | Back Directory | [density ]
1.962±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: >30mg/mL | [form ]
powder | [pka]
3.54±0.10(Predicted) | [color ]
white to faint yellow |
| Hazard Information | Back Directory | [Uses]
NS5806, a potent potassium current activator, increases KV4.3/KChIP2 peak current amplitudes with an EC50 of 5.3 μM. NS5806 slows KV4.3 and KV4.2 current dacay in channel complexes containing KChIP2[1]. | [Biochem/physiol Actions]
NS5806 increases peak current amplitude of the potassium channel Kv4.3 (EC50 = 5.3 uM). NS5806 also slows Kv4.3 and Kv4.2 current dacay in channel complexes containing KChIP2. In ventricular cardiomycytes, NS5806 increases transient outward current and reproduces the electrocardiographic profile of Brugada syndrome. | [storage]
Store at -20°C | [References]
[1] Lundby A, et al. Effect of the I(to) activator NS5806 on cloned KV4 channels depends on the accessory protein KChIP2. Br J Pharmacol. 2010 Aug;160(8):2028-44. doi: 10.1111/j.1476-5381.2010.00859.x. DOI:10.1111/j.1476-5381.2010.00859.x
[2] Cheng H, et al. Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Itomodulator NS5806. Physiol Rep. 2017 Mar;5(5). pii: e13172. DOI:10.14814/phy2.13172 |
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