| Identification | Back Directory | [Name]
(1R,4S)-Methyl 4-aMinocyclopent-2-enecarboxylate (Hydrochloride) | [CAS]
426226-35-9 | [Synonyms]
Peramivir Impurity 13 HCl
METHYL (1R,4S)-4-AMINOCYCLOPENT-2-ENE-1-CARBOXYLATE HCL
methyl(1R,4S)-4-aminocyclopent-2-ene-1-carboxylatehydrochloride
(1R,4S)-Methyl 4-aMinocyclopent-2-enecarboxylate (Hydrochloride)
Methyl (1R,4S)-4-amino-2-cyclopentene-1-carboxylate hydrochloride
(1R,4S)-4-Amino-2-cyclopentene-1-carboxylic Acid Methyl Ester Hydrochloride | [Molecular Formula]
C7H12ClNO2 | [MDL Number]
MFCD18207147 | [MOL File]
426226-35-9.mol | [Molecular Weight]
177.629 |
| Hazard Information | Back Directory | [Uses]
(1R,4S)-4-Amino-2-cyclopentene-1-carboxylic Acid Methyl Ester Hydrochloride is an intermediate used in the synthesis of ent-Abacavir (A105015), which is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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Hongdebiotech
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17712623939 |
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http://m.is0513.com/ShowSupplierProductsList1520360/0.htm |
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