| Identification | Back Directory | [Name]
PROTEIN C | [CAS]
42617-41-4 | [Synonyms]
APC
DP2.5
PROTEIN C
APC, HUMAN
APC protein
fromhumanplasma
HUMAN PROTEIN C
PROTEIN C, HUMAN
activated protein c
PROTEIN C, ACTIVATED
Native Human Protein C
PROTEIN C, HUMAN PLASMA
PROTEIN C CONTROL PLASMA
ACTIVATED HUMAN PROTEIN C
PROTEIN C, ACTIVATED, HUMAN
protein c from human plasma
BLOOD-COAGULATION FACTOR XIVA
PROTEIN C, ACTIVATED, HUMAN PLASMA
PROTEIN C, ACTIVATED FROM HUMAN PLASMA
adenomatous polyposis of the colon gene
protein C, des-1-41 light chain activated-
Anti-APC, C-Terminal antibody produced in rabbit
Protein C from human plasma Activated, lyophilized powder, >=90% (SDS-PAGE) | [MDL Number]
MFCD00165567 |
| Hazard Information | Back Directory | [Description]
Drotrecogin alfa was introduced in the US as a new intravenous treatment for the
reduction of mortality in adult patients with severe sepsis associated with acute organ
dysfunction. Drotrecogin aifa is the first recombinant activated protein C expressed in
human kidney 293 cells. Activated protein C1 an endogenous serine protease, acts as an
antithrombotic via inhibition of factor Va and Vllla, promotes fibrinolysis via inactivation of
plasminogen-activator inhibitor-1 and exerts an anti-inflammatory effect by inhibiting the
production of inflammatory cytokines (tumor necrosis factor-alpha, interieukin-1 and 6) by
monocytes. It was shown that the majority of patients with sepsis have reduced levels of
activated protein C. In a baboon model of lethal E. coli sepsis, administration of activated
protein C reduced mortality. In a phase III clinical trial, intravenous infusion of drotrecogin
alfa at a dose of 24 μg/kg/h over 96 h significantly reduced the risk of death compared with
placebo in patients with severe sepsis. However, an increased risk of serious bleeding has
been associated with the administration of the drug. | [Originator]
Lilly (US) | [Uses]
Protein C from human plasma has been used for pre-treatment of endothelial cells prior to antibody-inhibition assay. It has also been used in activated protein C (APC) assay to determine its inhibitory effect on copper. | [Brand name]
Xigris | [General Description]
Protein C from human plasma is encoded by the gene PROC. In human chromosome, the gene is localised on chromosome 2q14. Activated protein C (APC) cleaves protease activated receptor 1 (PAR1) resulting in cytoprotective and anti-inflammatory effects. Clinical trials with APC implicates its use in treating severe early onset preeclampsia in pregnant women and prolongs pregnancy and helps in perinatal outcomes. | [Biochem/physiol Actions]
Adenomatous Polyposis Coli (APC) has a key role in the proteasome-mediated degradation of β-catenin. APC mutations cause accumulation of β-catenin in the nucleus leading to activation of LEF-1 and/or TCF, and the induction of target genes such as the oncogene c-myc. It is involved in regulation of mitotic chromosome separation and stability. |
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