| Identification | Back Directory | [Name]
GPI choline | [CAS]
425642-32-6 | [Synonyms]
GPI choline
Glycerophosphoinositol choline
D-myo-Inositol, 1-[(2R)-2,3-dihydroxypropyl hydrogen phosphate], ion(1-), 2-hydroxy-N,N,N-trimethylethanaminium (1:1) | [Molecular Formula]
C14H32NO12P | [MOL File]
425642-32-6.mol | [Molecular Weight]
437.38 |
| Hazard Information | Back Directory | [Uses]
Glycerophosphoinositol choline is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders[1][2]. | [in vivo]
Glycerophosphoinositol choline (s.c., 0.2 and 100 mg/kg/h, 24 or 48 hours) can reduce postoperative injurious reflexes and effectively decreases tumor necrosis factor (TNF) release from macrophages in female C57/Bl6 mice[2].
| Animal Model: | Postoperative pain model of female C57/Bl6 mice[2] | | Dosage: | 0.2 and 100 mg/kg/h | | Administration: | Subcutaneous injection, 24 or 48 hours | | Result: | Reduced heat hypersensitivity after surgery with maximal efficacy after 48 h treatment and the ED50 value of choline dose was 1.7 mg/kg/h.
Reduced hypersensitivity to punctate mechanical stimuli 48 hours after infusion in a dose-dependent manner and with the ED50 value of 4.7 mg/kg/h but not 24 hours. |
| [IC 50]
Human Endogenous Metabolite | [References]
[1] M Q Holmes-McNary, et al. Apoptosis is induced by choline deficiency in fetal brain and in PC12 cells. Brain Res Dev Brain Res. 1997 Jul 18;101(1-2):9-16. DOI:10.1016/s0165-3806(97)00044-8
[2] T J Rowley, et al. Antinociceptive and anti-inflammatory effects of choline in a mouse model of postoperative pain. Br J Anaesth. 2010 Aug;105(2):201-7. DOI:10.1093/bja/aeq113 |
|
| Company Name: |
Puripharm Co., Ltd.
|
| Tel: |
0572-2745768-1 13167223168 |
| Website: |
http://www.puriactives.com/ |
|