| Identification | Back Directory | [Name]
4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide | [CAS]
420092-79-1 | [Synonyms]
SW155246
SW155246 >=98% (HPLC)
4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide
Benzenesulfonamide, 4-chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro- | [Molecular Formula]
C16H11ClN2O5S | [MOL File]
420092-79-1.mol | [Molecular Weight]
378.79 |
| Hazard Information | Back Directory | [Description]
SW155246 is an inhibitor of DNA methyltransferase 1 (DNMT1; IC50 = 1.2 μM). It is selective for human DNMT1 over murine DNMT3 (IC50 = 38 μM). SW155246 inhibits HeLa and A549 tumor cell growth in a redox-independent manner (IC50s = 8-20 μM). It also inhibits genomic methylation in HeLa cells when used at concentrations ranging from 10 to 18.6 μM. |
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