| Identification | Back Directory | [Name]
A[5']P5[5']A SODIUM SALT | [CAS]
4097-04-5 | [Synonyms]
A(5′)P5(5′)A
A[5']P5[5']A SODIUM SALT
DIADENOSINE PENTAPHOSPHATE SODIUM SALT
Diadenosine pentaphosphate pentasodium
5'-ester with adenosine pentasodium salt
P1,P5-Di(adenosine-5
Diadenosine pentaphosphate pentasodium salt
P1,P5-DI(ADENOSINE-5') PENTAPHOSPHATESOD IUM
P1,P5-DI(ADENOSINE-5') PENTAPHOSPHATE SODIUM SALT
Adenosine 5'-(hexahydrogen pentaphosphate) P''''→
P1,P5-di(adenosine-5')pentaphosphate pentasodium salt 5H2O
Adenosine-5'-pentaphosphateε-5'-adenosyl α,β,γ,δ,ε-pentasodium salt
P1,P5-Di(adenosine-5′) pentaphosphate pentasodium
P1,P5-Di(adenosine-5') pentaphosphate pentasodium salt
Adenosine 5'-(hexahydrogen pentaphosphate) P''''-5'-ester with adenosine pentasodium salt
Adenosine 5'-(hexahydrogen pentaphosphate), 5'->5'-ester with adenosine, pentasodium salt | [EINECS(EC#)]
223-852-7 | [Molecular Formula]
C20H24N10Na5O22P5 | [MDL Number]
MFCD00077718 | [MOL File]
4097-04-5.mol | [Molecular Weight]
1026.28 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
H2O: 50 mg/mL
| [form ]
powder
| [color ]
white to white with yellow cast
| [biological source]
synthetic (organic) | [Water Solubility ]
H2O: 50mg/mL | [BRN ]
4949216 |
| Hazard Information | Back Directory | [Uses]
P1,P5-Di(adenosine-5′) pentaphosphate pentasodium salt has been used as:
- an adenylate kinase (AK) inhibitor in: sarcoma osteogenic (Saos-2) cells
- mitochondrial lysates during ATP synthesis
- tetramethylrhodamine methyl ester (TMRM) based membrane potential assay
- chromoplasts
| [General Description]
P1,P5-Di(adenosine-5′) pentaphosphate (Ap5A) is a diadenosine polyphosphate, which has a tail-to-tail dimer structure. Ap5A is synthesized in a twostep process involving the formation of adenosine 5′-tetraphosphate (P4A) from the ATP and trimeta-phosphate (P3). In the second step, P4A is converted to Ap5A. The synthesis of Ap5A requires a pH optimum in the range of 7.5 to 8.5 and is modulated by metal ions. | [Biochem/physiol Actions]
A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor. |
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