| Identification | Back Directory | [Name]
4-[Tetrahydro-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-hydroxymethylfuran-2-yl]-1,2-benzenediol | [CAS]
40951-69-7 | [Synonyms]
Taxiresinol
4-[Tetrahydro-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-hydroxymethylfuran-2-yl]-1,2-benzenediol | [Molecular Formula]
C19H22O6 | [MDL Number]
MFCD06794931 | [MOL File]
40951-69-7.mol | [Molecular Weight]
346.37 |
| Chemical Properties | Back Directory | [Melting point ]
157-158 °C(Solv: methanol (67-56-1)) | [Boiling point ]
590.3±50.0 °C(Predicted) | [density ]
1.331±0.06 g/cm3(Predicted) | [pka]
9.60±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Taxiresinol is an orally active and potent lignan, that can be isolated from the heartwood of Taxus baccata. Taxiresinol shows significant antinociceptive activity[1]. | [in vivo]
Taxiresinol (100 mg/kg, oral administration, once) shows significant antinociceptive activity against p-benzoquinone-induced abdominal contractions in mice[1]. | Animal Model: | Male Swiss albino mice (20-25 g)[1] | | Dosage: | 100 mg/kg | | Administration: | Oral administration, sixty minutes after the oral administration of test sample, the mice were intraperitoneally injected with 0.1 ml/10 g body weight of 2.5% (v/v) p-benzoquinone solution in distilled H2O. | | Result: | Showed significant antinociceptive activity against p-benzoquinone-induced abdominal contractions (writhing movements) in mice, with a inhibitory ratio of 37.8%. |
| [References]
[1] Küpeli E, et al. Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L. J Ethnopharmacol. 2003 Dec;89(2-3):265-70. DOI:10.1071/bi9760365 |
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