| Identification | Back Directory | [Name]
8-Methoxyadenosine | [CAS]
3969-27-5 | [Synonyms]
8-Methoxyadenosine
Adenosine, 8-methoxy-
8-METHOXY-9-PENTOFURANOSYL-9H-PURIN-6-AMINE | [Molecular Formula]
C11H15N5O5 | [MOL File]
3969-27-5.mol | [Molecular Weight]
297.27 |
| Hazard Information | Back Directory | [Uses]
8-Methoxyadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1]. | [References]
[1] Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. DOI:10.1016/j.drudis.2021.02.020
[2] Cheeseman MD, Westwood IM, Barbeau O, et al. Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70. J Med Chem. 2016;59(10):4625-4636. DOI:10.1021/acs.jmedchem.5b02001 |
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