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ChemicalBook--->CAS DataBase List--->394668-43-0

394668-43-0

394668-43-0 Structure

394668-43-0 Structure
IdentificationBack Directory
[Name]

EBV lytic cycle inducer-1
[CAS]

394668-43-0
[Synonyms]

EBV lytic cycle inducer-1
[Molecular Formula]

C14H12BrN3O
[MOL File]

394668-43-0.mol
[Molecular Weight]

318.17
Chemical PropertiesBack Directory
[density ]

1.41±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
[form ]

Solid
[pka]

11.67±0.46(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Epstein-Barr virus (EBV) lytic cycle inducer-1 Dp44mT (compound C7) is an iron-chelatoe-like compound. Dp44mT cooperates with HDAC inhibitor Romidespin (HY-15149) and SAHA to induce EBV lytic cycle. Dp44mT reactivates EBV lytic cycle by activating the ERK1/2-autophagy axis in epithelial cancers[1][2].
[References]

[1] Chung King Choi, et al. Identification of Novel Small Organic Compounds with Diverse Structures for the Induction of Epstein-Barr Virus (EBV) Lytic Cycle in EBV-Positive Epithelial Malignancies. PLoS One. 2015 Dec 30;10(12):e0145994.
[2] Stephanie Pei Tung Yiu, et al. Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers Cancers 2018 Dec; 10(12): 505.
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