| Identification | Back Directory | [Name]
IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER | [CAS]
39028-27-8 | [Synonyms]
SIA
NHS IODOACETATE
SIA Crosslinker
Succinimidyl iodoacetate
N-IodoacetoxysucciniMide
N-SUCCINIMIDYL IODOACETATE
N-SucciniMidyl iodoacetate(SIA)
N-HYDROXYSUCCINIMIDYL IODOACETATE
2,5-Dioxopyrrolidin-1-yl 2-iodoacetate
2,5-Pyrrolidinedione, 1-[(iodoacetyl)oxy]-
IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER
N-HydroxysucciniMide Iodoacetic Acid Ester
Iodoacetic acid N-hydroxysuccinimide ester powder
Iodoacetic Acid N-Succinimidyl Ester
N-(Iodoacetoxy)succinimide | [Molecular Formula]
C6H6INO4 | [MDL Number]
MFCD00058451 | [MOL File]
39028-27-8.mol | [Molecular Weight]
283.02 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
148°C | [Boiling point ]
315.6±44.0 °C(Predicted) | [density ]
2.11±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
DMF: 50 mg/mL
| [form ]
powder
| [color ]
White to Off-White |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent.
Spacer Arm: 1.5 Angstroms | [Uses]
forms water soluble carboxylate derivatives | [Description]
SIA Crosslinker is a non-cleavable, water-soluble crosslinker containig an NHS ester and an iodine group. The NHS ester is reactive toward amines while the iodine reacts with thiol groups. | [reaction suitability]
reagent type: cross-linking reagent | [Biological Activity]
SIA Crosslinker is a non-cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs). | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
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