| Identification | Back Directory | [Name]
Proteasome Inhibitor XVI | [CAS]
389064-25-9 | [Synonyms]
Proteasome Inhibitor XVI
AdaAhxLVS - CAS 389064-25-9 - Calbiochem
L-Leucinamide, N-[1-oxo-6-[[1-oxo-6-[[1-oxo-6-[(2-tricyclo[3.3.1.13,7]dec-1-ylacetyl)amino]hexyl]amino]hexyl]amino]hexyl]-L-leucyl-N-[(1S)-3-methyl-1-[(1E)-2-(methylsulfonyl)ethenyl]butyl]- | [Molecular Formula]
C50H88N6O8S | [MOL File]
389064-25-9.mol | [Molecular Weight]
933.33 |
| Chemical Properties | Back Directory | [Boiling point ]
1161.4±65.0 °C(Predicted) | [density ]
1.096±0.06 g/cm3(Predicted) | [storage temp. ]
-20C | [solubility ]
DMSO: 5mg/mL | [form ]
Off-white powder | [pka]
13.41±0.46(Predicted) | [color ]
off-white |
| Hazard Information | Back Directory | [General Description]
A cell-permeable, peptide vinyl sulfone that acts as a potent, irreversible inhibitor of proteasome activity. Covalently modifies the catalytically active β-subunits of the proteasome. Shown to inhibit the chymotrypsin-like (10-50 nM), trypsin-like (1-5 μM), and the peptidyl glutamyl peptide hydrolyzing (PGPH) (0.5-1 μM) activities of purified 20S proteasomes from rabbit muscle. Inhibits proteasomal degradation of deglycosylated MHC HLA-A2 heavy chain in US11+ cells (~50 μM). | [Biochem/physiol Actions]
Cell permeable: yes |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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Alabiotech Inc.
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001-619-354-5251 |
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www.alabiotech-e.com |
| Company Name: |
Merck KGaA
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(+86) 21 2033 8288 |
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http://www.sigmaaldrich.cn |
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