| Identification | Back Directory | [Name]
LY 450108 | [CAS]
376594-67-1 | [Synonyms]
100782
LY 450108
LY 450108;LY-450108
Benzamide, 3,5-difluoro-N-[4-[(1R)-1-methyl-2-[[(1-methylethyl)sulfonyl]amino]ethyl]phenyl]-
N-[4-[(1R)-1-Methyl-2-[[(1-methylethyl)sulfonyl]amino]ethyl]phenyl]-3,5-difluorophenylcarboxamide | [Molecular Formula]
C19H22F2N2O3S | [MDL Number]
MFCD20526510 | [MOL File]
376594-67-1.mol | [Molecular Weight]
396.45 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 50 mg/mL (126.12 mM); Water: < 0.1 mg/mL (insoluble) | [form ]
Powder | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
LY450108 is a potent AMPA receptor potentiator. LY450108 has the potential for depression and Parkinson's disease research[1][2][3][4]. | [References]
[1] Simon E Ward1, Benjamin D Bax, Mark Harries. Challenges for and current status of research into positive modulators of AMPA receptors. British Journal of Pharmacology. 2010,160(2):181-190. DOI:10.1111/j.1476-5381.2010.00726.x
[2] O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20. DOI:10.2174/138945007780618517
[3] Jhee SS, Chappell AS, Zarotsky V, et al. Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects. J Clin Pharmacol. 2006 Apr;46(4):424-32. DOI:10.1177/0091270006286899
[4] Douglas A. Schober, Martin B. Gill, Hong Yu, et al. Transmembrane AMPA Receptor Regulatory Proteins and Cornichon-2 Allosterically Regulate AMPA Receptor Antagonists and Potentiators. The Journal of Biological Chemistry, 286, 13134-13142. DOI:10.1074/jbc.M110.212522 |
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