| Identification | Back Directory | [Name]
Deoxyphorbol | [CAS]
37415-57-9 | [Synonyms]
Deoxyphorbol
4-deoxy-4-Phorbol
4-deoxy-4α-Phorbol
(1aR)-1,1aα,1bβ,4,4aα,7aα,7b,8,9,9a-Decahydro-7bα,9β,9aα-trihydroxy-3-hydroxymethyl-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one
(1aR)-1,1,6,8α-Tetramethyl-3-(hydroxymethyl)-7bα,9β,9aα-trihydroxy-1,1aα,1bβ,4,4aα,7aα,7b,8,9,9a-decahydro-5H-cyclopropa[3,4]benzo[1,2-e]azulene-5-one | [Molecular Formula]
C20H28O5 | [MOL File]
37415-57-9.mol | [Molecular Weight]
348.43 |
| Chemical Properties | Back Directory | [Boiling point ]
531.9±50.0 °C(Predicted) | [density ]
1.311±0.06 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: slightly soluble; PBS (pH 7.2): 1 mg/ml | [form ]
A crystalline solid | [pka]
13.70±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
4-deoxy-4α-Phorbol is a tetracyclic diterpene found in croton oil.1,2 It has been used in the semisynthesis of inhibitors of the HIV-1-induced cytopathic effect on MT-4 cells and 4α-phorbol esters.
| [References]
1. El-Mekkawy, S., Meselhy, M.R., Abdel-Hafez, A.A., et al. Inhibition of cytopathic effect of human immunodeficiency virus type-1 by various phorbol derivatives Chem. Pharm. Bull. (Tokyo) 50(4),523-529(2002).
2. Klausen, T.K., Pagani, A., Minassi, A., et al. Modulation of the transient receptor potential vanilloid channel TRPV4 by 4α-phorbol esters: A structure-activity study J. Med. Chem. 52(9),2933-2939(2009). |
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