| Identification | Back Directory | [Name]
CYCLO(-GLY-PRO) | [CAS]
3705-27-9 | [Synonyms]
y-Pro)
cyclo-GP
cyclo(pro-gly)
CYCLO(-GLY-PRO)
Cyclic (Pro-Gly)
Cyclo(Gly-L-Pro)
Cycloglycylproline
Cyclo-L-prolylglycine
Cyclo(L-prolylglycyl)
Cycloglycyl-L-proline
Cyclo(glycyl-L-prolyl)
Glycyl-L-proline lactam
Cyclo(-Gly-Pro)≥ 99% (HPLC)
(S)-3,6-Dioxohexahydropyrrolo[1,2-a]pyrazine
(S)-Hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
(8AS)-HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE
(8aS)-octahydropyrrolo[1,2-a]piperazine-1,4-dione
Pyrrolo[1,2-a]pyrazine-1,4-dione,hexahydro-, (8aS)-
Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-, (8aS)- (9CI)
(8aS)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione | [Molecular Formula]
C7H10N2O2 | [MDL Number]
MFCD00055967 | [MOL File]
3705-27-9.mol | [Molecular Weight]
154.17 |
| Chemical Properties | Back Directory | [Melting point ]
220-223℃ | [Boiling point ]
447.9±34.0 °C(Predicted) | [density ]
1.32 | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMSO: >10mg/mL | [form ]
powder | [pka]
13.21±0.20(Predicted) | [InChIKey]
OWOHLURDBZHNGG-YFKPBYRVSA-N |
| Hazard Information | Back Directory | [Chemical Properties]
White crystal | [Uses]
Cyclo(-?Gly-?Pro) and its derivatives can be used as Cyclic Dipeptide Chitinase Inhibitors. It is also used to synthesize 5-HT1A receptor agonists. | [Biological Activity]
Cyclo-Gly-Pro is a neuro-protective compoundan endogenous diketopiperazinewhich enhances memory. In the animal model of PDthe compound improved functional recovery when administered after the onset of dyskinesia. It appears th at the compound recovery function may result from non-proliferative neurogenesis th at results from the inhibition of apoptosis of stem cells and/or the promotion of neuronal-orientated proliferation in the SVZ (subventricular zone). |
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