| Identification | Back Directory | [Name]
MPP+ IODIDE | [CAS]
36913-39-0 | [Synonyms]
4-phenylpyridin-1-ium iodide
1-methyl-4-phenylpyridin-1-ium
MPP+ IODIDE ISO 9001：2015 REACH
1-methyl-4-phenyl-pyridiniuiodide
N-Methyl-4-phenylpyridinium iodide
1-Methyl-4-phenylpyridin-1-iuM iodide
Pyridinium, 1-methyl-4-phenyl-, iodide
MPP+ iodide,1-Methyl-4-phenylpyridinium iodide
MPP+ IODIDE (ACTIVE METABOLITE OF DOPAMI NERGIC NEUROTOX | [Molecular Formula]
C12H12IN | [MDL Number]
MFCD00055096 | [MOL File]
36913-39-0.mol | [Molecular Weight]
297.135 |
| Chemical Properties | Back Directory | [Melting point ]
166-168 °C | [storage temp. ]
desiccated | [solubility ]
0.1 M HCl: soluble
| [form ]
solid
| [color ]
yellow
| [Water Solubility ]
H2O: 10mg/mL, clear | [InChIKey]
RFDFRDXIIKROAI-UHFFFAOYSA-M |
| Hazard Information | Back Directory | [Uses]
Dopaminergic neurotoxin; a selective cytostatic agent in small-cell lung cancer cell lines with neuroendocrine properties. | [General Description]
1-Methyl-4-phenylpyridinium (MPP+) induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide. | [Biochem/physiol Actions]
MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP. |
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