| Identification | Back Directory | [Name]
tolycaine | [CAS]
3686-58-6 | [Synonyms]
tolycaine
tolycaine USP/EP/BP
Methyl 2-(2-(diethylaMino)acetaMido)-3-Methylbenzoate
methyl 2-[[2-(diethylamino)acetyl]amino]-3-methylbenzoate
methyl 2-[2-(diethylamino)ethanoylamino]-3-methyl-benzoate
2-[2-(Diethylamino)acetylamino]-m-toluic acid methyl ester
2-[[2-(diethylamino)acetyl]amino]-3-methyl-benzoic acid methyl ester
Benzoic acid, 2-[[(diethylaMino)acetyl]aMino]-3-Methyl-, Methyl ester
Benzoic acid, 2-[[2-(diethylamino)acetyl]amino]-3-methyl-, methyl ester | [EINECS(EC#)]
222-976-9 | [Molecular Formula]
C15H22N2O3 | [MDL Number]
MFCD00864442 | [MOL File]
3686-58-6.mol | [Molecular Weight]
278.35 |
| Chemical Properties | Back Directory | [Melting point ]
<25 °C | [Boiling point ]
bp5 190-192° | [density ]
1.113±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 100 mg/mL (359.26 mM) | [form ]
Liquid | [pka]
13.61±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Originator]
Tolycaine
Hydrochloride,ZYF Pharm Chemical | [Definition]
ChEBI: Tolycaine is an amidobenzoic acid. | [Manufacturing Process]
A suspension of 40 g 2-amino-3-methylbenzoic acid methyl ester in 125 ml of
benzene was added 125 ml of saturated solution of sodium acetate and then
at 0-5°C was added 37 g chloracetylchloride. The mixture was stirred for 1
hour at room temperature. The mixture was filtered. The organic layer was
with 10% solution of potassium carbonate and dries under calcium chloride.
By distillation of the mixture was obtained 15 g of 2-(2-chloroacetylamino)-3-methylbenzoic acid methyl ester; melting point 86-87.5°C (crystallization from
a mixture acetic acid and ligroin); yield 21.8 g.
A mixture of 16 g of 2-(2-chloroacetylamino)-3-methylbenzoic acid methyl
ester and 10 g diethyl amine in benzene was refluxed for 5 hours. After
cooling the diethyl amine hydrochloride was deleted by filtration. The organic
layer was washed with 2 N hydrochloric acid. To the solution was added
potassium carbonate. The product was extracted with ether and distilled. | [Brand name]
Tolycaine Hydrochloride is
JAN. | [Therapeutic Function]
Local anesthetic | [storage]
Store at -20°C |
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MedChemExpress
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