| Identification | Back Directory | [Name]
MST-312 | [CAS]
368449-04-1 | [Synonyms]
MST-312
MST-312 >=98% (HPLC)
TELOMERASE INHIBITOR IX
N,N′-1,3-Phenylenebis-[2,3-dihydroxy-benzamide]
Benzamide, N,N'-1,3-phenylenebis[2,3-dihydroxy-
N,N'-BIS(2,3-DIHYDROXYBENZOYL)-1,3-PHENYLENEDIAMINE
Telomerase Inhibitor IX - CAS 368449-04-1 - Calbiochem
N-[3-[(2,3-dihydroxybenzoyl)amino]phenyl]-2,3-dihydroxybenzamide
EGCG,Telomerase,epigallocatechin,gallate,Inhibitor,multiple,tea,MST-312,derivative,cancer,MST 312,inhibit,MST312,myeloma | [Molecular Formula]
C20H16N2O6 | [MDL Number]
MFCD06411458 | [MOL File]
368449-04-1.mol | [Molecular Weight]
380.35 |
| Chemical Properties | Back Directory | [Boiling point ]
526.7±50.0 °C(Predicted) | [density ]
1.578±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥20mg/mL | [form ]
White solid | [pka]
7.70±0.35(Predicted) | [color ]
off-white to light tan |
| Hazard Information | Back Directory | [Uses]
MST-312 has been used in cell invasion assay using mouse fibroblast cells (NIH-3T3) and in the co-immunoprecipitation experiments in colon fibroblast. | [Definition]
ChEBI: N-[3-[[(2,3-dihydroxyphenyl)-oxomethyl]amino]phenyl]-2,3-dihydroxybenzamide is a member of benzamides. | [General Description]
A cell-permeable, bis-catechol containing, m-phenylenediamide compound that displays anti-proliferative properties. Acts as a potent, reversible inhibitor of telomerase activity (IC50 = 670 nM, TRAP lysate prepared from U937 cells). Prolonged treatment with MST-312 has been reported to result in telomere shortening and growth arrest in U937 cells. Does not inhibit the activity of Taq DNA polymerase (IC50 >3 μM). | [Biochem/physiol Actions]
Cell permeable: yes | [storage]
Store at -20°C |
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