| Identification | Back Directory | [Name]
SILYBIN (MIXTURE OF SILYBIN A AND SILYBIN B) | [CAS]
36804-17-8 | [Synonyms]
Silybin
Silybin A，SB-A
Silibinin, 98%(total of isomers)
(Mixture of Silybin A and Silybin B)
Silybin(mixtureofSilybinAandSilybinB)>
SILYBIN (MIXTURE OF SILYBIN A AND SILYBIN B)
2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-(3,5,7-trihydroxy-4-oxobenzopyran-2-yl)benzodioxine
Silibinin
2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-(3,5,7-trihydroxy-4-oxobenzopyran-2-yl)benzodioxine
(2R,3R)-3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydro-4H-chromen-4-one
4H-1-Benzopyran-4-one, 2-[(2R,3R)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-rel- | [Molecular Formula]
C25H22O10 | [MDL Number]
MFCD00872186 | [MOL File]
36804-17-8.mol | [Molecular Weight]
482.44 |
| Chemical Properties | Back Directory | [Melting point ]
160 °C | [Boiling point ]
793.0±60.0 °C(Predicted) | [density ]
1.527±0.06 g/cm3(Predicted) | [storage temp. ]
Freezer | [form ]
powder to crystaline | [pka]
7.39±0.60(Predicted) | [color ]
White to Orange to Green | [Merck ]
14,8532 |
| Hazard Information | Back Directory | [Uses]
(±)-Silybin is the racemate of Silybin (HY-N0779A). Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2]. | [Definition]
ChEBI: Silibinin is a flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities. It has a role as an antioxidant, an antineoplastic agent, a hepatoprotective agent and a plant metabolite. It is a flavonolignan, a polyphenol, an aromatic ether, a benzodioxine and a secondary alpha-hydroxy ketone. | [References]
[1] Silvia Zappavigna, et al. Silybin-Induced Apoptosis Occurs in Parallel to the Increase of Ceramides Synthesis and miRNAs Secretion in Human Hepatocarcinoma Cells. Int J Mol Sci. 2019 May 3;20(9):2190. DOI:10.3390/ijms20092190
[2] Runbin Sun, et al. Silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD mouse model. Biomed Pharmacother. 2020 Mar;123:109721. DOI:10.1016/j.biopha.2019.109721 |
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