| Identification | Back Directory | [Name]
Hh-Ag 1.3 | [CAS]
364590-63-6 | [Synonyms]
Hh-Ag 1.3
Smoothened Agonist, HCl
SAG . dihydrochloride (water soluble)
3-Chloro-N-[4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide
3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide,hydrate,dihydrochloride | [Molecular Formula]
C28H28ClN3OS | [MDL Number]
MFCD14636155 | [MOL File]
364590-63-6.mol | [Molecular Weight]
490.06 |
| Chemical Properties | Back Directory | [Boiling point ]
688.6±55.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 10mg/mL
water: 25mg/mL | [form ]
White to off-white solid. | [pka]
10?+-.0.40(Predicted) | [color ]
light yellow | [Water Solubility ]
Soluble in water. | [Sensitive ]
Light Sensitive & Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Smoothened Agonist, HCl (SAG), is a highly potent activator of Smo (smoothened). This chlorobenzothiophene compound is a hedgehog pathway agonist that interacts with the heptahelical domain of Smo. SAG is shown to act as an activator at low concentrations, but can inhibit Smo coupling at very high concentrations. The activating effects of SAG will counteract Cyclopamine or Cyclopamine-KAAD inhibition of Smo. | [in vivo]
SAG (1.0 mM) induces more osteogenesis mainly at the defect borders and a significant increase in BV/TV at the eight-week timepoint in CD-1 mice[4].
SAG (15-20 mg/kg; i.p.) induces pre-axial polydactyly prevalently in a dose-dependent manner in mice[5]. |
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Energy Chemical
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