| Identification | Back Directory | [Name]
(22R)-5α-Lanosta-8,24-diene-3β,22-diol | [CAS]
35963-37-2 | [Synonyms]
Inotodiol
Inonotus obliquus alcohol
(22R)-5α-Lanosta-8,24-diene-3β,22-diol
(22R)-5α-Lanosta-8,24-diene-3β,22-diol
Lanosta-8,24-diene-3,22-diol, (3β,22R)-
(3beta,5xi,22R)-lanosta-8,24-diene-3,22-diol | [Molecular Formula]
C30H50O2 | [MDL Number]
MFCD11840685 | [MOL File]
35963-37-2.mol | [Molecular Weight]
442.73 |
| Chemical Properties | Back Directory | [Melting point ]
191-193 °C | [Boiling point ]
534.3±50.0 °C(Predicted) | [density ]
1.03±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [form ]
Solid | [pka]
14.97±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Inotodiol activates p53 signaling pathway, inhibits MMP-2/9, and exhibits antitumor activity in cancer cell HeLa. Inotodiol inhibits the generation of ROS and exhibits antioxidant and neuroprotective effects. Inotodiol inhibits the activation of MAPK and NF-κB signaling pathway, and exhibits anti-inflammatory activity. Inotodiol inhibits TLR-4 mediated TNF-α production (IC50 in BMMC and BMDM is 0.7 μM and 3.0 μM), inhibits the degranulation in mast cell, exhibits anti-allergic activity. Inotodiol is orally active[1][2][3][4][5]. | [in vivo]
Inotodiol (2-20 mpk, po, once daily for 3-5 days) inhibits allergic reactions in passive systemic anaphylaxis and passive cutaneous anaphylaxis, exhibits antiasthmatic activity in mouse models[5]. | Animal Model: | Mouse passive anaphylaxis models[5] | | Dosage: | 2-20 mpk | | Administration: | po, once daily for 3-5 days | | Result: | Reduced the decrease in body temperature and ear swelling. |
| [References]
[1] Nakata T, et al. Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus. Bioorg Med Chem. 2007;15(1):257-264. DOI:10.1016/j.bmc.2006.09.064
[2] Zhang SD, et al., Inotodiol inhibits cells migration and invasion and induces apoptosis via p53-dependent pathway in HeLa cells. Phytomedicine. 2019 Jul;60:152957. DOI:10.1016/j.phymed.2019.152957
[3] Li Y, et al. Inotodiol protects PC12 cells against injury induced by oxygen and glucose deprivation/restoration through inhibiting oxidative stress and apoptosis[J]. Journal of Applied Biomedicine, 2018, 16(2): 126-132.
[4] Lee SH, et al., Antiaging effect of inotodiol on oxidative stress in human dermal fibroblasts. Biomed Pharmacother. 2022 Sep;153:113311. DOI:10.1016/j.biopha.2022.113311
[5] Liu Y, et al., Inotodiol, an antiasthmatic agent with efficacy and safety, preferentially impairs membrane-proximal signaling for mast cell activation. Int Immunopharmacol. 2023 Apr;117:109854. DOI:10.1016/j.intimp.2023.109854 |
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