| Identification | Back Directory | [Name]
3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone | [CAS]
35773-42-3 | [Synonyms]
EMI1 (EGFR MaMTH Inhibitor 1)
3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone
3-(Benzoxazol-2-yl)-7-diethylamino-2H-1-benzopyran-2-one
3-(1,3-benzoxazol-2-yl)-7-(diethylamino)-2H-chromen-2-one
2H-1-Benzopyran-2-one, 3-(2-benzoxazolyl)-7-(diethylamino)-
3-(Benzoxazole-2-yl)-7-(diethylamino)-2H-1-benzopyran-2-one
7-(Diethylamino)-3-(benzoxazole-2-yl)-2H-1-benzopyran-2-one | [EINECS(EC#)]
252-721-7 | [Molecular Formula]
C20H18N2O3 | [MOL File]
35773-42-3.mol | [Molecular Weight]
334.37 |
| Hazard Information | Back Directory | [Uses]
EMI1 is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S inhibitor. EMI1 can be used for the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC)[1]. | [Biological Activity]
EMI1 (ChemBridge 5213777) is a call penetrant and potent inhibitor of EGFR signaling in EGFR L858R/T790M/C797S and ex19del/T790M/C797S triple mutants associated with drug-resistant NSCLC. AdditionallyEMI1 potently depolymerized interphase microtubulesdisrupts spindle formation and induced mitotic block in PC9 EGFR ex19del/T790M/C797S cells. EMI1 exhibits potent anti-proliferative activity against various cancer cell lines. | [IC 50]
EGFRdel19 T790M C797S; EGFRL858R/T790M/C797S | [References]
[1] Punit Saraon, et al. A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Nat Chem Biol. 2020 May;16(5):577-586. DOI:10.1038/s41589-020-0484-2 |
|
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
http://m.is0513.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
nanjing
|
| Tel: |
13376082704 13376082704 |
| Website: |
www.linye-e.com/ |
| Company Name: |
Merck KGaA
|
| Tel: |
(+86) 21 2033 8288 |
| Website: |
http://www.sigmaaldrich.cn |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
www.biorbyt.com |
|