| Identification | Back Directory | [Name]
cynaropicrin | [CAS]
35730-78-0 | [Synonyms]
Cynaropikrin
cynaropicrin
CYNAROPICRIN(SH)
Cynaropicrin - Cynara cardunculus (artichoke)
2-Hydroxymethylpropenoic acid (3aR,4S,6aβ,9aβ,9bα)-dodecahydro-8α-hydroxy-3,6,9-tris(methylene)-2-oxoazuleno[4,5-b]furan-4-yl ester
2-Propenoic acid, 2-(hydroxymethyl)-, (3aR,4S,6aR,8S,9aR,9bR)-dodecahydro-8-hydroxy-3,6,9-tris(methylene)-2-oxoazuleno[4,5-b]furan-4-yl ester
2-methylolacrylic acid [(3aR,4S,6aR,8S,9aR,9bR)-8-hydroxy-2-keto-3,6,9-trimethylene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-4-yl] ester
[(3aR,4S,6aR,8S,9aR,9bR)-8-hydroxy-3,6,9-trimethylidene-2-oxo-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-4-yl] 2-(hydroxymethyl)prop-2-enoate | [Molecular Formula]
C19H22O6 | [MDL Number]
MFCD31614147 | [MOL File]
35730-78-0.mol | [Molecular Weight]
346.37 |
| Chemical Properties | Back Directory | [Boiling point ]
566.2±50.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
-20°C, protect from light | [solubility ]
DMSO:50.0(Max Conc. mg/mL);144.35(Max Conc. mM) | [form ]
Oil | [pka]
13.52±0.10(Predicted) | [color ]
Off-white to light yellow | [LogP]
1.340 (est) |
| Hazard Information | Back Directory | [Uses]
Cynaropicrin can inhibit lipopolysaccharide-induced TNF-α release from either murine or human macrophage cells in a dose-dependent manner with the IC50 values of 8.24 and 3.18 μM, respectively. It can also inhibit the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling. | [Definition]
ChEBI: Cynaropicrin is a sesquiterpene lactone. |
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