| Identification | Back Directory | [Name]
(13E,15S)-15-Hydroxy-9-oxoprosta-11,13-dien-1-oic acid | [CAS]
35687-86-6 | [Synonyms]
PGC1
LEM6
PGC1A
PGC-1v
PPARGC1
PPARGC1A
PGC-1(alpha)
Prostaglandin C1
ANTI-PPARGC antibody produced in rabbit
ANTI-PPARGC1A antibody produced in mouse
MONOCLONAL ANTI-PPARGC antibody produced in mouse
Monoclonal Anti-PPARGC1A antibody produced in mouse
(13E,15S)-15-Hydroxy-9-oxoprosta-11,13-dien-1-oic acid | [Molecular Formula]
C20H32O4 | [MOL File]
35687-86-6.mol | [Molecular Weight]
336.47 |
| Chemical Properties | Back Directory | [Boiling point ]
521.9±30.0 °C(Predicted) | [density ]
1.094±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
buffered aqueous solution | [pka]
4.77±0.10(Predicted) | [biological source]
rabbit |
| Hazard Information | Back Directory | [Definition]
ChEBI: Prostaglandin C1 is a prostaglandins C. It is a conjugate acid of a prostaglandin C1(1-). | [Biological Activity]
PPARG coactivator 1 α (PPARGC1A) interacts with a wide range of transcription factors and plays a vital role in cellular energy metabolism. The encoded protein regulates activity of many transcription factors and functions as a molecular switch for various cellular processessuch as mitochondrial biogenesis and respirationgluconeogenesis and glucose transportglycogenolysisfatty acid oxidationperoxisomal remodelingmuscle fiber-type switching and oxidative phosphorylation. Additionallyit is also acts as a regulator of Type 2 diabetes mellitus (T2DM) and is considered to be a potential target for anti-diabetic therapy. The protein functions as a tumor suppressor in hepatocellular carcinoma and can be used as a promising therapeutic target for the same. It is downregulated in prostate cancer. Presence of PPARGC1A inhibits prostate cancer progression and metastasis. Howeverpresence of this protein gives selective advantages in breast cancer and melanoma cells. |
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