| Identification | Back Directory | [Name]
Z-LEU-LEU-GLU-AMC | [CAS]
348086-66-8 | [Synonyms]
Z-LLE-AMC
Z-ILE-AMC
Z-LLG-AMC
Z-LEU-LEU-GLY-AMC
Z-LEU-LEU-GLU-AMC
Z-LEU-LEU-GLU-MCA
CBZ-LEU-LEU-GLU-AMC
Proteasome Substrate II
Cbz-Leu-Leu-Glu-AMC, Z-LLE-AMC
PROTEASOME SUBSTRATE II (FLUOROGENIC)
Z-LEU-LEU-GLU-7-AMIDO-4-METHYLCOUMARIN
Z-LEU-LEU-GLU-7-AMINO-4-METHYLCOUMARIN
benzyloxycarbonyl-L-leucyl-L-leucyl-L-glutamic acid α-(4-methylcoumaryl-7-amide)
CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-GLUTAMIC-ACID-ALPHA-(4-METHYLCOUMARINYL)-7-AMIDE
BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-GLUTAMIC ACID ALPHA-(4-METHYLCOUMARYL-7-AMIDE)
L-α-Glutamine, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
N-[(Phenylmethoxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-alpha-glutamine
(5S,8S,11S)-5,8-Diisobutyl-11-((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatetradecan-14-oic acid | [Molecular Formula]
C35H44N4O9 | [MDL Number]
MFCD01074989 | [MOL File]
348086-66-8.mol | [Molecular Weight]
664.75 |
| Chemical Properties | Back Directory | [Boiling point ]
967.8±65.0 °C(Predicted) | [density ]
1.253±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble | [form ]
solid | [pka]
4.43±0.10(Predicted) | [color ]
Solid lyophilized powder |
| Hazard Information | Back Directory | [Description]
Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment. | [Uses]
A fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (caspase-like) activity of the proteasome which may be stimulated in the presence of Mg2+ ions and rapidly inactivated by N-acetylimidazole | [Uses]
Z-Leu-Leu-Glu-7-amido-4-methylcoumarin has been used as a fluorogenic substrate for peptidyl glutamyl peptide hydrolase (PGPH) in rat soleus muscle, neonatal cardiomyocytes and rat brain samples. | [General Description]
Z-Leu-Leu-Glu-7-amido-4-methylcoumarin is a fluoropeptide. It acts as a substrate for caspase-like activity. | [Biochem/physiol Actions]
Fluorogenic substrate for the measurement of the peptidylglutamyl-peptide hydrolyzing activity of the 20S proteasome. | [storage]
+4°C |
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Sigma-Aldrich
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