| Identification | Back Directory | [Name]
2-MONOOLEIN | [CAS]
3443-84-3 | [Synonyms]
2-MONOOLEIN
2-oleoylglycerol
Glycerin 2-oleate
L-Glycerol 2-oleate
2-MONOOLEOYLGLYCEROL
2-O-Oleoyl-L-glycerol
2-O-Oleoyl-sn-glycerol
2-Oleoyl Glycerol (80%)
2-monooleoylglycerol(c18:1
1,3-Dihydroxypropan-2-yl oleate
2-MONOOLEOYLGLYCEROL (C18:1, (CIS)-9)
9-Octadecenoic acid (9Z)-, 2-hydroxy-1-(hydroxymethyl)ethyl ester
9-Octadecenoic Acid (Z)- , 2-hydroxy-1-(hydroxyMethyl) ethyl ester | [Molecular Formula]
C21H40O4 | [MDL Number]
MFCD00171536 | [MOL File]
3443-84-3.mol | [Molecular Weight]
356.54 |
| Chemical Properties | Back Directory | [Melting point ]
23-23.5 °C | [Boiling point ]
485.4±35.0 °C(Predicted) | [density ]
0.9963 g/cm3 | [Fp ]
113 °C | [storage temp. ]
−20°C
| [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly) | [form ]
Oil | [pka]
13.54±0.10(Predicted) | [color ]
Colourless | [Stability:]
Temperature Sensitive |
| Hazard Information | Back Directory | [Chemical Properties]
Clear Colourless Oil | [Uses]
A metabolite of 2-acylglycerol
Contain up to 20% 1-isomer. | [Definition]
ChEBI: A 2-monoglyceride where the acyl group is (9Z)-octadecenoyl. | [Biological Activity]
2-oleoyl glycerol (2-OG) acts as an agonist for G protein-coupled receptor 119 (GPR119) in vitro and stimulates glucagon-like peptide-1 (GLP-1) secretion in vivo. | [in vivo]
2-Oleoylglycerol (20 μg/mouse in 0.2 mL PBS, i.v., three times a week for 6 weeks) induces liver fibrosis in a non-alcoholic steatohepatitis (NASH) model through promoting TGF-β1 production in liver MΦs[3]. | Animal Model: | C57BL/6 J mice, CL-HFS-induced non-alcoholic steatohepatitis (NASH) model[3] | | Dosage: | 20?μg/mouse in 0.2?mL PBS | | Administration: | Intravenous administration (I.V.), three times a week for 6 weeks | | Result: | Showed increased hepatic infiltration of inflammatory cells, increased collagen and α-SMA production; 2-OG enhanced liver resident MΦ and HSC activation. |
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Alfa Chemistry
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BOC Sciences
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Energy Chemical
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