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ChemicalBook--->CAS DataBase List--->34233-69-7

34233-69-7

34233-69-7 Structure

34233-69-7 Structure
IdentificationBack Directory
[Name]

CLOZAPINE N-OXIDE
[CAS]

34233-69-7
[Synonyms]

CLOZAPINE N-OXIDE
Clozapine N-oxide solution
Clozapine N-oxide Methanol Adduct
e)(1,4)diazepine,8-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(n-oxide
8-CHLORO-11-[4-METHYL-1-PIPERAZINYL]-5H-DIBENZO[B,E][1,4]DIAZEPINE N-OXIDE
[Molecular Formula]

C18H19ClN4O
[MDL Number]

MFCD00210190
[MOL File]

34233-69-7.mol
[Molecular Weight]

342.82
Chemical PropertiesBack Directory
[Appearance]

Yellow Solid
[Melting point ]

190-248°C
[Fp ]

9℃
[storage temp. ]

-20°C Freezer, Under Inert Atmosphere
[solubility ]

Soluble in DMSO.
[form ]

powder
[pka]

6.86±0.20(Predicted)
[color ]

Yellow
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
[InChIKey]

OGUCZBIQSYYWEF-UHFFFAOYSA-N
Hazard InformationBack Directory
[Chemical Properties]

Yellow Solid
[Uses]

A 5-HT2 antagonist. A major metabolite of clozapine that can be monitored by HPLC. Possesses little or no activity towards serotonin receptors
[Description]

Clozapine-N-oxide (34233-69-7) is a clozapine?metabolite1?which is pharmacologically inert2. Agonist at human muscarinic designer receptors known as DREADDs, (designer receptors exclusively activated by designer drug).2?May be used to control grafted human pluripotent stem cell-derived neurons engineered to express DREADDs.3,4??Numerous other applications.5,6
[Definition]

ChEBI: Clozapine N-oxide is a dibenzodiazepine.
[General Description]

Clozapine N-oxide (CNO), inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its passage through blood-brain barrier.
[Biochem/physiol Actions]

5-HT2 serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.
[storage]

Room temperature (desiccate)
[References]

1) Eiermann?et al.?(1997),?The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine; Br. J. Clin. Pharmacol.,?44?439 2) Armbruster?et al.?(2007),?Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand; Proc. Natl. Acad. Sci. USA,?104?5163 3) Chen?et al.?(2016),?Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson’s Disease; Cell Stem Cell,?18?817 4) Vazey and Aston-Jones (2014),?Designer receptors: therapeutic adjuncts to cell replacement therapy in Parkinson’s disease: J. Clin. Invest.,?124?2858 5) Gomez?et al.?(2017)?Chemogenetics revealed: DREADD occupancy and activation via converted clozapine; Science?357?503 6) Marcinkiewcz?et al. (2016)?Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala; Nature?537?97
Safety DataBack Directory
[Hazard Codes ]

Xn,T,F
[Risk Statements ]

22-36/37/38-39/23/24/25-23/24/25-11
[Safety Statements ]

26-36-45-36/37-16-7
[RIDADR ]

UN 2811 6.1/PG 3
[WGK Germany ]

3
[RTECS ]

HP1760000
[HazardClass ]

6.1(b)
[PackingGroup ]

III
[HS Code ]

29335990
Spectrum DetailBack Directory
[Spectrum Detail]

CLOZAPINE N-OXIDE(34233-69-7)1HNMR
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