| Identification | Back Directory | [Name]
ETHYLHYDROCUPREINE HYDROCHLORIDE | [CAS]
3413-58-9 | [Synonyms]
neumolisina
OptochineHCl
optochinhydrochloride
optoquinhydrochloride
numoquinhydrochloride
OPTICHIN HYDROCHLORIDE
Ethylhydrocupreine HCI
ETHYLHYDROCUPREINE HYDROCHLORIDE
o-ethyl-hydrocupreinhydrochloride
Ethylhydrocupreine HCl,Optochin HCl
hydrocupreine,ethylester,hydrochloride
ETHYLHYDROCUPREINE HYDROCHLORIDE*CRYSTAL LINE
(R)-(6-ethoxyquinolin-4-yl)-[(2S,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]methanol | [EINECS(EC#)]
222-302-3 | [Molecular Formula]
C21H29ClN2O2 | [MDL Number]
MFCD00135594 | [MOL File]
3413-58-9.mol | [Molecular Weight]
376.92 |
| Chemical Properties | Back Directory | [Melting point ]
121-123°C | [alpha ]
D21 -123.6° (water) | [storage temp. ]
2-8°C
| [solubility ]
DMSO : 125 mg/mL (331.64 mM; Need ultrasonic) | [form ]
neat | [color ]
White to off-white | [Sensitive ]
Light Sensitive | [BRN ]
4055970 |
| Hazard Information | Back Directory | [Uses]
Ethylhydrocupreine Hydrochloride is a reagent used in the alteration in bacterial morphology. Also, it inhibits methylene blue (MB) reductase activity; Anti-pneumococcal analog of quinine-HC1 which stimulated the diaphorase activity of pig heart muscle and Escherichia coli lipoyl dehydrogenase. | [in vivo]
The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs[1]. | [IC 50]
Plasmodium | [storage]
4°C, protect from light | [Purification Methods]
Recrystallise it from H2O [UV: Heidt & Forbes J Am Chem Soc 55 2701 1933]. [Beilstein 24 H 385, 24 III/IV 1446.] |
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