| Identification | Back Directory | [Name]
WAY-353603 | [CAS]
340221-20-7 | [Synonyms]
WAY-353603
sEH inhibitor-7
2-Cyclohexyl-N-(4-methoxyphenyl)acetamide
Cyclohexaneacetamide, N-(4-methoxyphenyl)- | [Molecular Formula]
C15H21NO2 | [MOL File]
340221-20-7.mol | [Molecular Weight]
247.33 |
| Chemical Properties | Back Directory | [Boiling point ]
435.2±28.0 °C(Predicted) | [density ]
1.080±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
14.44±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
sEH inhibitor-7 (compound c-2) is an inhibitor of soluble epoxide hydrolase (sEH) with IC50s of 0.15 μM (mouse sEH) and 6.2 μM (human sEH), respectively. soluble epoxide hydrolase (sEH) plays an important role in the metabolism of endogenous chemical mediators involved in the regulation of blood pressure and inflammation[1]. | [References]
[1] Kim IH, et al. Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9. DOI:10.1021/jm0500929 |
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