| Identification | Back Directory | [Name]
Necrostatin-5 | [CAS]
337349-54-9 | [Synonyms]
Necrostatin-5
Necrostatin-5 (Nec-5)
Necrostatin-5 >=98% (HPLC), solid
3-p-methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide
2-[[3,4,5,6,7,8-Hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-acetonitrile
Acetonitrile, 2-[[3,4,5,6,7,8-hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]- | [Molecular Formula]
C19H17N3O2S2 | [MDL Number]
MFCD01448275 | [MOL File]
337349-54-9.mol | [Molecular Weight]
383.49 |
| Hazard Information | Back Directory | [Biological Activity]
Necrostatin-5 is an inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase. Necroptosis is defined as alternative active cell death pathway: Death-Domain Receptor (DRse.g. Fas/TNFR) mediated and caspase-inhibitor insensitive with specific morphology (nuclear condensationorganelle swellingloss of plasma membrane integrity). The necrostatins have been discovered to inhibit this pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5since necrostatin-5 is a potent inhibitor of immunnoprecipitated RIP1but does not inhibit recombinant RIP1. | [storage]
Store at -20°C |
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Alfa Chemistry
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