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ChemicalBook--->CAS DataBase List--->330829-30-6

330829-30-6

330829-30-6 Structure

330829-30-6 Structure
IdentificationBack Directory
[Name]

N-[[[3-[(Benzoyl)amino]phenyl]amino](thioxo)methyl]-3,4,5-trimethoxybenzamide
[CAS]

330829-30-6
[Synonyms]

MRT-10
MRT-10 >=98% (HPLC)
N-((3-Benzamidophenyl)carbamothioyl)-3,4,5-trimethoxybenzamide
N-({[3-(benzoylamino)phenyl]amino}carbonothioyl)-3,4,5-trimethoxybenzamide
Benzamide, N-[[[3-(benzoylamino)phenyl]amino]thioxomethyl]-3,4,5-trimethoxy-
N-[[[3-[(Benzoyl)amino]phenyl]amino](thioxo)methyl]-3,4,5-trimethoxybenzamide
[Molecular Formula]

C24H23N3O5S
[MDL Number]

MFCD02734587
[MOL File]

330829-30-6.mol
[Molecular Weight]

465.52
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: ≥15mg/mL
[form ]

powder
[color ]

white to tan
Safety DataBack Directory
[Symbol(GHS) ]


GHS05,GHS09
[Signal word ]

Danger
[Hazard statements ]

H318-H410
[Precautionary statements ]

P273-P280-P305+P351+P338-P501
[Hazard Codes ]

Xi,N
[Risk Statements ]

41-50
[Safety Statements ]

26-39-61
[RIDADR ]

UN 3077 9 / PGIII
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

MRT10 is an antagonist of the Smoothened (Smo) receptor with an IC50 value of 0.64 μM in a luciferase reporter assay. It also inhibits bodipy-cyclopamine binding to the murine Smo receptor (IC50 = 0.5 μM) when expressed in HEK293 cells.
[Uses]

MRT 10, is a novel, high-affinity antagonist smoothened (Smo) receptor antagonist. It displaces labeled cyclopamine from Smo with an IC50 of 500 nM, and inhibits shh-induced Gli-reporter activity in Shh-light2 cells (IC50 = 0.64 μM).
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