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IdentificationBack Directory
[Name]

2,6-Dichloropurine -9-beta-D-(2'-deoxy-3',5'-di-O-benzoyl-2'-fluoro)arabinoriboside
[Synonyms]

2,6-Dichloro-9-(2-deoxy- 2-fluoro-β-D-arabinofuranosyl)-9H-purine
2,6-Dichloro-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranosyl)-9H-purine
2,6-Dichloropurine -9-beta-D-(2'-deoxy-3',5'-di-O-benzoyl-2'-fluoro)arabinoriboside
((2R,3R,4S,5R)-3-(Benzoyloxy)-5-(2,6-dichloro-9H-purin-9-yl)-4-fluorotetrahydrofuran-2-yl)methyl benzoate
[MDL Number]

MFCD15145239
[MOL File]

329187-80-6.mol
Chemical PropertiesBack Directory
[Melting point ]

157-159 °C
[Boiling point ]

631.9±65.0 °C(Predicted)
[density ]

1.57±0.1 g/cm3(Predicted)
[pka]

-1.40±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

2,6-Dichloro-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranosyl)-9H-purine arabinoriboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
[References]

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
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