| Identification | Back Directory | [Name]
TYLOPHORIDICINE A(), 98+% | [CAS]
32523-69-6 | [Synonyms]
Tylophorinidine
TYLOPHORIDICINE A(), 98+%
(13aS,14S)-3,7-dimethoxy-9,11,12,13,13a,14-hexahydrophenanthro[10,9-f]indolizine-6,14-diol
(13aS,14S)-9,11,12,13,13a,14-Hexahydro-3,7-dimethoxydibenzo[f,h]pyrrolo[1,2-b]isoquinoline-6,14-diol
(12aS,13S)-3,7-Dimethoxy-6,13-dihydroxy-9,10,11,12,12a,13-hexahydro-9a-aza-9aH-cyclopenta[b]triphenylene
Dibenzo[f,h]pyrrolo[1,2-b]isoquinoline-6,14-diol, 9,11,12,13,13a,14-hexahydro-3,7-dimethoxy-, (13aS,14S)- | [Molecular Formula]
C22H23NO4 | [MOL File]
32523-69-6.mol | [Molecular Weight]
365.42 |
| Hazard Information | Back Directory | [Description]
The most recently discovered of the Tylophora alkaloids, this base is found in
the roots of T. asthmatica and has [α]25D + 108° (c 1.91, MeOH). The ultraviolet
spectrum in MeOH has absorption maxima at 258, 286.5, 310, 339.5 and 355
Mu. Two methoxyl groups and two phenolic hydroxyl groups are present and
the alkaloid furnishes the O,O-dimethyl ether, m.p. 2l8-2200 C (dec.) and the
diacetate, m.p. 192°C. | [Uses]
Tylophorinidine is used in biological studies for thymidylate synthase in leukocytes from patients with chronic myelocytic leukemia and acute lymphocytic leukemia. It allows for inhibition of pergularinine and tylophorinidine (Erratum). | [References]
Mulchandani, Iyer, Badheka., Chem. Ind., 505 (1971) |
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