| Identification | Back Directory | [Name]
inh-02
(RNF5 inhibitor inh-02) | [CAS]
324579-65-9 | [Synonyms]
RNF5 inhibitor Inh-2
RNF5 inhibitor inh-02
inh-02
(RNF5 inhibitor inh-02)
Benzenecarboximidamide, N-[3-methyl-4-(phenylmethyl)-1,2,4-thiadiazol-5(4H)-ylidene]-N'-phenyl-
RNF5 inhibitor Inh-2 (E)-N-((Z)-4-benzyl-3-methyl-1,2,4-thiadiazol-5(4H)-ylidene)-N'-phenylbenzimidamide | [Molecular Formula]
C23H20N4S | [MDL Number]
MFCD01849637 | [MOL File]
324579-65-9.mol | [Molecular Weight]
384.5 |
| Hazard Information | Back Directory | [Biological Activity]
RNF5 inhibitor inh-02 is a potent inhibitor of E3 ubiquitin ligase RNF5/RMA1. RNF5 inhibitor inh-02 leads to significant F508del-CFTR rescue (EC50=2.2 uM) in bronchial epithelial cells homozygous for the F508del mutation. RNF5 inhibitor inh-02 can be used for cystic fibrosis research[1]. | [References]
[1]. Elvira Sondo, et al. Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia. Cell Chem Biol. 2018 Jul 19;25(7):891-905.e8. |
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